![]() High levels of SHBG lock up free testosterone making it unavailable to support mood or metabolism. ![]() However, this represents only a tiny amount of the total testosterone equal to only to 2% of the total in men and even less in women. Since only free testosterone easily crosses into the brain, muscles, and fat cells much of the desirable action of testosterone has to do with the free portion. Free testosterone refers to defraction of testosterone that circulates in the blood and is not associated with or bound by SHBG (Sex Hormone Binding Globulin), its carrier protein. DIM, through its effects on estrogen metabolism supports testosterone by helping to maintain the level of free or active testosterone. Testosterone acts differently depending on whether it is free or bound to carrier proteins in the blood. How does DIM benefit testosterone activity? Testosterone has a clear anti-depressant action and promotes interest in sex and men and women. The more subtle effects of testosterone have to do with its action as a support for mood and libido. This process also increase metabolic rate and consumes fat, resulting in a leaner physique. Active protein synthesis produce bigger muscles and stronger bones, especially in response to exercise. Testosterone is also identified as anabolic hormone due to its ability to promote protein synthesis. These include male distribution of body hair, a deeper voice, and male genital development. Testosterone is known as an androgen because when its effect dominate male characteristics are seen. Testosterone is an important contributor to healthy hormonal balance in both men and women. Following the quotations is a partial bibliography substantiating the claims made in the article. Scott Connelly, M.D., based on research related to men’s use of diindolylmethane (DIM) and the phytochemical compounds (indole-3-carbinol) found in cruciferous vegetables from which DIM is derived. The following quotations are taken from All about DIM by Michael A. Fruit and vegetable intakes and prostate cancer risk. “A recent study of Seattle men showed that three or more servings of cruciferous vegetables a week can reduce prostate cancer risk almost by half.” His statement is based on an article by J. of DIM (or its equivalent in raw cruciferous vegetables) reduce your risk for prostate cancer? DIM, has been shown in scientific studies to reduce the risk of prostate and other hormone-driven cancers by helping the body to make a better balance of the hormones.*Ĭan taking 250 – 300 mg. Increased consumption of cruciferous vegetables is associated with reduced tumor incidents in humans and experimental animals.ĭiindolylmethane (DIM, in short) is the principal breakdown product of indole 3-carbinol (I3C), the phytochemical found in cruciferous vegetables like cabbage, cauliflower, broccoli, brussel sprouts, kale, collards, mustard greens, radishes, watercress, and turnips. The cruciferous vegetables, such as cabbage and broccoli are particularly rich sources of such compounds, including Indole derivatives, dithilthiones and isothiocyanates. In conclusion, DIM (i) had side effect on some sperm characteristics, (ii) increased the MDA levels and (iii) led to histological degeneration of testicular tissues and apoptosis in a dose-dependent manner.Īndrogen receptors apoptosis diindolylmethane male reproductive system rat.Several classes of chemical compounds which naturally occur in fruits and vegetables possess anticarcenogenic properties. ![]() Only, DIM-10 showed anti-estrogenic activity as compared to higher DIM groups. Only DIM-50 had an anti-androgenic effect among all groups. ![]() Sperm density was higher in DIM-10 groups when compared to both other groups. While DIM-10 did not affect abnormal sperm rate, higher concentrations increased the abnormalities. It decreased motility and live sperm rates and increased degeneration of testicular tissues. Histopathological examinations of tests were done. Spermatological parameters, malondialdehyde (MDA) levels of testes and serum T and E2 levels were assayed. ![]() Rats were divided into four groups: Group I: referred as Control group, received corn oil only Group II: as DIM-10, rats received 10 mg kg -1 DIM Group III: as DIM-50, rats received 50 mg kg -1 DIM Group IV: as DIM-100, received 100 mg kg -1 DIM during 53 days. Thirty-eight male Sprague Dawley rats were used. This study aimed to investigate the effects of DIM on sperm parameters, histological structures of testicular tissues, blood testosterone (T) and estradiol 17-β (E2) in male rats. 3,3 Diindolylmethane (DIM) is a major digestive product of indole-3 carbinol, obtained from Brassica family vegetables such as broccoli, cabbage and Brussels sprouts. ![]()
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